FIG. 2.

Network of protein–protein interactions involving APE1 (adapted from ref. 51). APE1 plays an essential role in BER through its enzymatic activity as well as its role in coordinating interactions, either directly (solid lines) or indirectly (dashed lines), with a large number of other proteins involved in BER. Proteins highlighted are central components with APE1, apurinic/apyrimidinic endonuclease, in the middle. Those proteins in the first column are DNA glycosylases; the remaining proteins include PCNA, an accessory protein; polymerases, pol β and pol δ; ligase 1, LIG1; and the flap endonuclease, FEN1.