FIG. 7.

Ceramide metabolism. Scheme depicting the different pathways that lead to the generation (e.g., de novo synthesis in the endoplasmic reticulum and hydrolysis of sphingomyelin by sphingomyelinases), or catabolism (e.g., synthesis of gangliosides in the Golgi, and generation of ceramide-1-phosphate and sphingosine-1-phosphate) of ceramide.