Table 1.

Expression of Pro- or Antioxidants Changes with Aging (in VSMC or Aorta Tissue)

Name	Pro-/anti-oxidants	Functions	Changes with aging	References
Nox, Nox1,2,4	Pro-	O2• production	↑	71, 86
XO	Pro-	O2• production	↑	82
NOS, iNOS	Pro- & Anti-	Nitric oxide synthesis	↑	13, 18, 25
GPx	Anti-	H2O2 → H2O	↑	22
GCL, GCLC	Anti-	Glutathione synthesis	↑	62
HO, HO1	Anti-	Heme → Fe2+, CO	↑	81
MnSOD	Anti-	O2• → H2O2	↓	60, 70, 120
Cu2+ Zn2+ dismutase	Anti-	O2• → H2O2	↓	25
Catalase	Anti-	H2O2 → H2O	↓	22
NO	Pro- & Anti-		↓	35, 110
GSH	Anti-	H2O2 → H2O	↓	60, 103