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. Author manuscript; available in PMC: 2011 Apr 29.
Published in final edited form as: Neuron. 2010 Apr 29;66(2):191–197. doi: 10.1016/j.neuron.2010.03.017

Figure 2. Inhibition of endogenous MEF2 function enhances synapse number in wildtype, but not in Fmr1 KO neurons.

Figure 2

A, Representative traces of mEPSCs (upper; scale bar = 10 pA/500 ms.) and evoked EPSCs (lower; scale bar = 50 pA/10 ms) from a simultaneous recording from an untransfected and neighboring MEF2-Engrailed (MEF2-EN) transfected WT neuron. B. Average mEPSC frequency, mEPSC amplitude, evoked EPSC amplitude, and paired-pulse ratio from untransfected WT and MEF2-EN transfected cells. Averages are plotted + SEM and n (# of cell pairs) is indicated on each bar. * p< 0.05. C, D MEF2-EN transfection into Fmr1 KO slice cultures. C. Representative traces of mEPSCs (upper; scale bar = 10 pA/500 ms.) and evoked EPSCs (lower; scale bar = 50 pA/10 ms) from a simultaneous recording of an untransfected and neighboring MEF2-EN transfected Fmr1 KO neuron. D. Average mEPSC frequency, mEPSC amplitude, evoked EPSC amplitude, and paired-pulse ratio from untransfected and MEF2-EN transfected Fmr1 KO neurons.