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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Trends Microbiol. 2010 Feb 20;18(5):215–223. doi: 10.1016/j.tim.2010.01.001

Figure 3. MiRNAs and pre-miRNAs generated by MCV and JCV.

Figure 3

MiRNAs for MCV [37] and JCV [36] have recently been reported. Alignment of stem-and-loop structures for an MCV pre-miRNA (a) and a JCV pre-miRNA (b) are shown and have been adapted from the mirbase website (www.mirbase.org). Sequences of the 22 nt miRNAs are shown in pink lettering. A perfect match between mcv-miR-M1-5p and a DNA sequence encoding a segment of MCV large T-antigen is shown in (c). As shown in Figure 2, this sequence is N-terminal to the Rb-binding motif of MCV T-antigen.