Table 1.
Clinical, demographic, and neuropathological characteristics by diagnosis category
| Clinical Diagnosis |
Comparison by diagnosis group | |||||
|---|---|---|---|---|---|---|
| NCI (N=10) | MCI (N=10) | AD (N=10) | Total (N=30) | |||
| Age at death (years): | Mean ± SD (Range) | 82.3 ± 4.5 (76–90) | 84.1 ± 5.7 (72–92) | 90.2 ± 7.3 (80–101) | 85.5 ± 6.7 (72–101) | p = 0.05a |
| Number (%) of males: | 5 (50%) | 4 (40%) | 3 (30%) | 12 (40%) | p = 0.9b | |
| Years of education: | Mean ± SD (Range) | 19.4 ± 3.2 (15–25) | 20.0 ± 2.1 (17–24) | 17.9 ± 2.6 (14–22) | 19.1 ± 2.7 (14–25) | p = 0.2a |
| Number (%) with ApoE ε4 allele: | 0 | 0 | 4 (40%) | 4 (13%) | p = 0.5b | |
| MMSE: | Mean ± SD (Range) | 28.2 ± 1.0 (27–30) | 28.1 ± 1.8 (25–30) | 16.4 ± 5.8 (7–24) | 24.2 ± 6.6 (7–30) | p < 0.0001a* |
| Global Cognitive Score (GCS): | Mean ± SD (Range) | 0.71 ± 0.24 (0.37–1.20) | 0.39 ± 0.32 (−0.17, 0.83) | −0.81 ± 0.52 (−1.52, −0.16) | 0.13 ± 0.75 (−1.52, 1.20) | p < 0.0001a* |
| Postmortem interval (hours): | Mean ± SD (Range) | 5.1 ± 3.0 (2.3–12.4) | 4.7 ± 2.4 (2.7–10.0) | 6.1 ± 3.5 (2.7–12.4) | 5.3 ± 2.9 (2.3–12.4) | p = 0.7a |
| Distribution of Braak scores: | I-II | 4 | 5 | 0 | 9 | p = 0.0003a* |
| III-IV | 6 | 5 | 4 | 15 | ||
| V-VI | 0 | 0 | 6 | 6 | ||
| Distribution of NIA Reagan diagnosis (likelihood of AD): | No AD | 0 | 0 | 0 | 0 | p = 0.0005a* |
| Low | 5 | 7 | 0 | 12 | ||
| Intermediate | 5 | 3 | 5 | 13 | ||
| High | 0 | 0 | 5 | 5 | ||
a
Kruskal-Wallis test.
b
Fisher's exact test.
*
Pairwise comparisons with Bonferroni correction showed that there was no significant difference between NCI and MCI, but both were significantly different from AD (p<0.01).