Table 2.
Genotype and allele frequencies in the extreme morning, intermediate, and extreme evening preference groups (n = 80 in each group), and DSPD patients (n = 23) for the four PER3 promoter region polymorphisms.
| Genotype frequencies |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G-320T |
C-319A |
-318 VNTR |
G-294A |
|||||||||
| GG | GT | TT | CC | CA | AA | 1/1 | 1/2 | 2/2 | GG | GA | AA | |
| Morning | 0.93 | 0.01 | 0.06 | 0.93 | 0.01 | 0.06 | 0 | 0.03 | 0.97 | 0.86 | 0.11 | 0.03 |
| Intermediate | 0.85 | 0.06 | 0.09 | 0.70 | 0.21 | 0.09 | 0 | 0 | 1.0 | 0.86 | 0.14 | 0 |
| Evening | 0.95 | 0.01 | 0.04 | 0.91 | 0.05 | 0.04 | 0 | 0.03 | 0.97 | 0.74 | 0.25 | 0.01 |
| DSPD | 0.83 | 0 | 0.17 | 0.83 | 0 | 0.17 | 0 | 0 | 1.0 | 0.83 | 0.17 | 0 |
| Allele frequencies | ||||||||
|---|---|---|---|---|---|---|---|---|
| G-320T |
C-319A |
-318 VNTR |
G-294A |
|||||
| G | T | C | A | 1 | 2 | G | A | |
| Morning | 0.93 | 0.07 | 0.93 | 0.07 | 0.01 | 0.99 | 0.92 | 0.08 |
| Intermediate | 0.88 | 0.12 | 0.81 | 0.19 | 0 | 1.0 | 0.93 | 0.07 |
| Evening | 0.96 | 0.04 | 0.94 | 0.06 | 0.01 | 0.99 | 0.86 | 0.14 |
| DSPD | 0.83 | 0.17 | 0.83 | 0.17 | 0 | 1.0 | 0.91 | 0.09 |
| P values, odds ratio, 95% confidence intervals |
||||
|---|---|---|---|---|
| M vs I | 0.001, 3.26, 1.57-6.74 | |||
| I vs E | 0.023, 2.95, 1.20-7.22 | 0.001, 3.61, 1.70-7.64 | ||
| M vs D | 0.042, 2.85, 1.07-7.58 | 0.042, 2.85, 1.07-7.58 | ||
| E vs D | 0.006, 4.60, 1.57-13.48 | 0.033, 3.16, 1.17-8.55 | ||
P values are given for statistically significant comparisons of allele frequencies between morning (M), intermediate (I), evening (E), and DSPD (D) groups, followed by odds ratios and 95% confidence intervals.