Table 1.
Characteristics of Study Groups
| Characteristics | Mild Group | Severe Group | ||
|---|---|---|---|---|
| Control (n=496666) |
Psoriasis (n=129143) |
Control (n=14330) |
Psoriasis (n=3603) |
|
| Sex | ||||
| Male | 198498 (40.0%) |
61956 (48.0%) | 5783 (40.4%) | 1750 (48.6%) |
| Female | 298168 (60.0%) |
67187 (52.0%) p < 0.001 |
8547 (59.6%) | 1853 (51.4%) p < 0.001 |
|
| ||||
| Age, y | ||||
| Mean ± SD | 46.1 ± 19.1 | 45.1 ± 17.8 | 49.7 ± 19.3 | 52.2 ± 16.7 |
| Median (IQR) | 43, 30, 61 | 42, 30, 59 p < 0.001 Wilcoxon test |
48, 33, 65 | 52, 39, 66 p < 0.001 Wilcoxon test |
|
| ||||
| Diabetes mellitus | ||||
| Yes | 22296 (4.5%) | 5858 (4.5%) | 737 (5.1%) | 270 (7.5%) |
| No | 474370 (95.5%) |
123285 (95.5%) p = 0.470 |
13593 (94.9%) | 3333 (92.5%) p < 0.001 |
|
| ||||
| History of Stroke | ||||
| Yes | 7401 (1.5%) | 1648 (1.3%) | 268 (1.9%) | 89 (2.5%) |
| No | 489265 (98.5%) |
127495 (98.7%) p < 0.001 |
14062 (98.1%) | 3514 (97.5%) p = 0.023 |
|
| ||||
| History of TIA | ||||
| Yes | 5637 (1.1%) | 1254 (1.0%) | 243 (1.7%) | 68 (1.9%) |
| No | 491029 (98.9%) |
127889 (99.0%) p < 0.001 |
14087 (98.3%) |
3535 (98.1%) p = 0.432 |
|
| ||||
| History of Stroke or TIA |
||||
| Yes | 11883 (2.4%) | 2655 (2.1%) | 450 (3.1%) | 140 (3.9%) |
| No | 484783 (97.6%) |
126488 (97.9%) p < 0.001 |
13880 (96.9%) | 3463 (96.1%) p = 0.028 |
|
| ||||
| Hyperlipidemia | ||||
| Yes | 22839 (4.6%) | 6775 (5.2%) | 842 (5.9%) | 250 (6.9%) |
| No | 473827 (95.4%) |
122368 (94.8%) p < 0.001 |
13488 (94.1%) | 3353 (93.1%) p = 0.019 |
|
| ||||
| Hypertension | ||||
| Yes | 88397 (17.8%) | 22829 (17.7%) | 3049 (21.3%) | 858 (23.8%) |
| No | 408269 (82.2%) |
106314 (82.3%) p = 0.313 |
11281 (78.7%) | 2745 (76.2%) p = 0.001 |
|
| ||||
| Smoking | ||||
| Never | 383824 (77.3%) |
96944 (75.1%) | 10465 (73.0%) | 2488 (69.1%) |
| Current | 19839 (4.0%) | 5866 (4.5%) | 755 (5.3%) | 241 (6.7%) |
| Former | 93003 (18.7%) | 26333 (20.4%) p < 0.001 |
3110 (21.7%) | 874 (24.3%) p < 0.001 |
|
| ||||
| BMI | ||||
| < 25 | 166470 (53.2%) |
40606 (49.6%) | 5057 (51.2%) | 1025 (42.1%) |
| ≥ 25 & < 30 | 100551 (32.1%) |
27701 (33.8%) | 3291 (33.3%) | 860 (35.4%) |
| ≥ 30 | 45977 (14.7%) | 13618 (16.6%) p < 0.001 |
1522 (15.4%) | 548 (22.5%) p < 0.001 |
|
| ||||
| Reason for end of Study |
||||
| Death | 32677 (6.6%) | 7302 (5.6%) | 790 (5.5%) | 297 (8.2%) |
| End of UTS | 353565 (71.2%) |
95275 (73.8%) | 11247 (78.5%) | 2860 (79.4%) |
| Transfer out | 110424 (22.2%) |
26566 (20.6%) p < 0.001 |
2293 (16.0%) | 446 (12.4%) p < 0.001 |
|
| ||||
| Atrial fibrillation | ||||
| Yes | 12861 (2.6%) | 3046 (2.4%) | 428 (3.0%) | 99 (2.8%) |
| No | 485486 (97.4%) |
126117 (97.6%) p < 0.001 |
13963 (97.0%) | 3505 (97.3%) p = 0.507 |
Abbreviations: TIA, transient ischemic attack, BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); SD, standard deviation; IQR, interquartile range
Data for BMI were available for 67% of the patients.
Unless notes otherwise, p-values are derived using Fisher exact test