Table 4.

Unadjusted and Adjusted Cox Proportional Hazard Regression Models of the Risk of Stroke in Patients Mild and Severe Psoriasis Compared with Control Patients

Covariate	Model Hazard Ratio (95% CI)
	Mild Psoriasis	Severe Psoriasis
Unadjusted Analysis
Psoriasis	0.91 (0.86, 0.95)	1.38 (1.05, 1.80
Adjusted for Age and Sex
Psoriasis	1.07 (1.02, 1.12)	1.44 (1.10, 1.88)
Age per year	1.089 (1.087, 1.090)	1.09 (1.08, 1.10)
Sex (Male)	1.27 (1.22, 1.32)	1.51 (1.20, 1.91)
Primary Model (Adjusted for Major Cardiovascular Risk Factors)*
Psoriasis	1.06 (1.01, 1.11)	1.43 (1.10, 1.87)
Age per year	1.082 (1.081, 1.084)	1.08 (1.07, 1.09)
Diabetes	1.78 (1.69, 1.87)	1.60 (1.16, 2.19)
Hx of Stroke	4.26 (4.01, 4.51)	3.65 (2.57, 5.18)
Hx of TIA	2.01 (1.87, 2.16)	2.05 (1.40, 3.01)
Hyperlipidemia	1.12 (1.04, 1.20)	1.35 (0.92, 1.98)
Hypertension	1.49 (1.43, 1.55)	1.72 (1.35, 2.18)
Sex (Male)	1.20 (1.16, 1.25)	1.42 (1.12, 1.80)
Smoking (current vs never)	0.97 (0.89, 1.06)	1.09 (0.71, 1.68)
Smoking (former vs never)	1.10 (1.03, 1.17)	1.24 (0.89, 1.73)

Abbreviations: CI, confidence interval; TIA, transient ischemic attack; HR, hazard ratio;

^*BMI was not included in the primary analysis as these data are only available in about 65% of patients. BMI analyses are shown in Table 5. Interaction terms for sex and age were not statistically significant (P<0.05).