Table 1.
Characteristics of kidney donors, overall and by age group, presented as mean ± SD or frequency (%)
| Characteristic | Overall n=1203 | 18-29 y n=148 | 30-39 y n=303 | 40-49 y n=392 | 50-59 y n=257 | 60-69 y n=92 | 70-77 y n=11 | Trend Test p-value† |
|---|---|---|---|---|---|---|---|---|
| Age, y | 44 ± 11 | 25 ± 3 | 35 ± 3 | 45 ± 3 | 54 ± 3 | 64 ± 3 | 72 ± 2 | |
| Male |
510 (42%) |
74 (50%) |
143 (47%) |
153 (39%) |
93 (36%) |
43 (47%) |
4 (36%) |
.038 |
| Kidney Function | ||||||||
| 24-h urine protein, mg | 46 ± 28 | 44 ± 24 | 42 ± 23 | 46 ± 29 | 47 ± 31 | 52 ± 29 | 62 ± 58 | 0.002 |
| 24-h urine albumin, mg | 6.2 ± 9.2 | 6.6 ± 7.8 | 6.1 ± 6.2 | 6.2 ± 9.7 | 5.4 ± 11 | 6.8 ± 8.7 | 14 ± 25 | 0.96 |
| Serum creatinine, mg/dl | 0.89 ± 0.16 | 0.88 ± 0.15 | 0.90 ± 0.15 | 0.90 ± 0.17 | 0.88 ± 0.16 | 0.91 ± 0.16 | 0.89 ± 0.12 | 0.57 |
| Estimated GFR, ml/min/1.73 m2 | 81 ± 14 | 94 ± 14 | 84 ± 13 | 79 ± 13 | 77 ± 12 | 74 ± 10 | 70 ± 7 | <0.001 |
| Measured.GFR, ml/min/1.73 m2 | 104 ± 17 | 114 ± 19 | 110 ± 18 | 103 ± 15 | 97 ± 14 | 90 ± 12 | 86 ± 11 | <0.001 |
| Chronic kidney disease* |
55 (4.8%) |
2 (1.4%) |
8 (2.8%) |
12 (3.2%) |
22 (8.9%) |
10 (12%) |
1 (11%) |
<0.001 |
| Blood Pressure | ||||||||
| 18-h mean systolic BP, mmHg | 119 ± 9 | 118 ± 8 | 118 ± 9 | 118 ± 9 | 120 ± 10 | 124 ± 11 | 126 ± 9 | <0.001 |
| 18-h mean active systolic BP, mmHg | 122 ± 10 | 121 ± 9 | 122 ± 10 | 121 ± 10 | 123 ± 11 | 128 ± 12 | 129 ± 12 | <0.001 |
| 18-h mean nocturnal systolic BP, mmHg | 108 ± 10 | 108 ± 8 | 107 ± 9 | 107 ± 10 | 108 ± 10 | 110 ± 11 | 112 ± 10 | 0.18 |
| 18-h mean diastolic BP, mmHg | 73 ± 7 | 70 ± 6 | 72 ± 6 | 73 ± 7 | 74 ± 7 | 74 ± 8 | 76 ± 8 | <0.001 |
| 18-h mean active diastolic BP , mmHg | 75 ± 8 | 73 ± 7 | 75 ± 7 | 76 ± 8 | 76 ± 8 | 76 ± 10 | 79 ± 10 | <0.001 |
| 18-h mean nocturnal diastolic BP, mmHg | 63 ± 8 | 60 ± 7 | 62 ± 7 | 63 ± 8 | 64 ± 8 | 64 ± 8 | 66 ± 10 | <0.001 |
| Hypertension (on therapy) |
71 (5.9%) |
0 (0.0%) |
6 (2.0%) |
18 (4.6%) |
26 (10%) |
18 (20%) |
3 (27%) |
<0.001 |
| Other CKD Risk Factor | ||||||||
| Family history of ESRD | 699 (58%) | 106 (72%) | 192 (63%) | 238 (61%) | 115 (45%) | 43 (47%) | 5 (45%) | <0.001 |
| Body mass index, kg/m2 | 2 ± 5 | 27 ± 5 | 28 ± 6 | 28 ± 6 | 28 ± 5 | 28 ± 5 | 26 ± 4 | 0.31 |
| Body mass index > 30 kg/m2 | 333 (30%) | 33 (22%) | 101 (33%) | 124 (32%) | 71 (28%) | 33 (36%) | 1 (9.1%) | 0.55 |
| Total cholesterol, mg/dl | 197 ± 37 | 170 ± 30 | 192 ± 38 | 200 ± 36 | 210 ± 34 | 203 ± 38 | 202 ± 36 | <0.001 |
| Triglycerides, mg/dl | 127 ± 95 | 113 ± 85 | 130 ± 73 | 132 ±127 | 123 ± 74 | 127 ± 71 | 100 ± 42 | 0.90 |
| High density cholesterol, mg/dl | 57 ± 16 | 51 ± 12 | 53 ± 14 | 57 ± 16 | 62 ± 18 | 60 ± 17 | 66 ± 15 | <0.001 |
| Low density cholesterol, mg/dl | 116 ± 35 | 99 ± 36 | 114 ± 38 | 120 ± 35 | 123 ± 30 | 116 ± 35 | 116 ± 31 | <0.001 |
| Glucose, mg/dl | 95 ± 9 | 91 ± 8 | 94 ± 8 | 95 ± 9 | 98 ± 8 | 99 ± 9 | 97 ± 7 | <0.001 |
| Uric acid, mg/dl | 5.2 ± 1.4 | 5.3 ± 1.4 | 5.3 ± 1.5 | 5.0 ± 1.3 | 5.0 ± 1.3 | 5.5 ± 1.4 | 5.6 ± 1 | 0.64 |
*
Chronic kidney disease defined by an estimated GFR <60 ml/min/1.73 m2 or a 24-h urine albumin >30 mg. Physicians relied more on measured GFR than estimated GFR at the time of donor selection.
†
Trend test was the p-value for Pearson's correlation between the characteristic and age (continuous).
SD = standard deviation, BP = blood pressure. GFR = glomerular filtration rate