The upper panels show the Ca2+ concentration distribution on the composite grid at time t = 0.025 ms (left) and at t = 0.225 ms (right). The lower panels show Ca2+ concentration profiles through the center of the domain. In each of these lower panels, the dotted curve shows the concentration profile at t = 0.025 ms, and the solid curve shows the concentration profile at t = 0.225 ms. In the lower left panel the concentrations at the two times are plotted as functions of x for fixed y, and in the lower right panel they are plotted as functions of y for fixed x. As the elliptical membrane becomes more circular, the concentration profiles shift accordingly. The membrane is only slightly permeable to Ca2+. Note the buildup of Ca2+ adjacent to the membrane, which contributes to the space-charge layer.