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In vivo effect of NCI-172033 on the ACCase, PCCase and FAS I activities of M. smegmatis. Cultures of M. smegmatis were incubated in the presence of 100 μM NCI-172033 and the relative acetyl- and propionyl-CoA-dependent carboxylases and FAS I activities determined in the cell-free extracts. Cerulenin, a known inhibitor of the β-ketoacyl synthase domain in type I synthases, was used as a control.
