Table S1.

Matrix effects from different sources of plasma (EDTA as the antocoagulant). Plasma samples spiked with lumefantrine at 900 ng/mL.

Plasma (lot #)	Replicate	Anticoagulant	Conc. (LF) ng/mL	Theoretical conc (units) ng/mL	Mean ng/mL	SD	% CV	% Dev
1 (23-08172)	1	EDTA	855	900	845	22.1	2.6%	−6.1
	2	EDTA	861	900
	3	EDTA	820	900
2 (23-08176)	1	EDTA	853	900	895	37.6	4.2%	−0.5
	2	EDTA	908	900
	3	EDTA	925	900
3 (23-08180)	1	EDTA	864	900	903	34.1	3.8%	0.3
	2	EDTA	918	900
	3	EDTA	927	900
4 (55-20429)	1	EDTA	950	900	947	17.2	1.8%	5.2
	2	EDTA	962	900
	3	EDTA	928	900
5 (23-06316)	1	EDTA	920	900	929	8.1	0.9%	3.2
	2	EDTA	930	900
	3	EDTA	936	900
6 (22-97035)	1	EDTA	899	900	939	36.5	3.9%	4.4
	2	EDTA	949	900
	3	EDTA	970	900