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Several similarities and differences between the vaccinia and adenovirus systems exist
| Vaccinia | Ad-T7 | |
|---|---|---|
| T7 polymerase delivery | Vaccinia virus | Adenovirus |
| Cytotoxicity | Yes | No |
| HCV replication | (+) and (−) strand synthesis; high levels |
(+) and (−) strand synthesis; low but effective levels |
| Duration of replication | 24 h | 9 days |
| HCV protein production | Yes | Yes |
| Quasispecies generation | Yes | Yes |
| IFN inhibits replication | Yes | Yes |
