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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: Circulation. 2010 Apr 6;121(13):1518–1522. doi: 10.1161/CIRCULATIONAHA.109.904235

Table 1.

Health Effects of Light and Intermittent Smoking

Disease Level of Smoking Risk for Light smokers vs. Nonsmokers Study Design

Cardiovascular Disease

Ischemic Heart Disease (28) 1–4 cig/day RR: 2.74 (2.07–3.61) men
RR 2.94 (1.75–4.95) women
Prospective Cohort

Aortic Aneurysm (30) < 10 cig/ day RR: 2.29 Prospective Cohort

Cardiovascular Mortality
(31)
Occasional smoking RR: 1.5 in men (1.0–2.3) Prospective Cohort

Malignancy

Esophageal Cancer (32) 1–14 cig/day RR: 4.25 Prospective Cohort

Lung Cancer (28) 1–4 cig/day RR: 2.79 (0.94–8.28) in men
RR 5.03 (1.81 to 13.98) in women
Prospective Cohort

Gastric Cancer (33) 1–4 cig/day RR: 2.4 (1.3 – 4.3) Case-Control

Pancreatic Cancer (34) < 10 cig/ day RR: 1.8 (1.4 – 2.5) Prospective Cohort

Respiratory Diseases

Lower Respiratory Tract
Infections (35)
Light Smoking (< 1
pack/ day)
RR: 1.5 in men; RR: 1.13 in women Prospective Cohort

Prolonged Duration of
Respiratory Symptoms:
Cough (35)
< 1 pack/day Duration of respiratory symptoms (cough) was
7.7 days in the light smoking group vs. 6.8 days
in never smokers
Prospective Cohort

Reproductive Health

Impaired Fecundity in
Women
(Delayed time to
Conception) (36)
1–4 cig/day Increasing OR of delayed conception from 1.1
for 6 month delay to 3.2 at 18 month delay
Prospective Cohort

Spermatozoa Function (36) 4 cig/day over 5
years
Spermatozoa showed decreased density/motility Prospective Cohort

Placenta Previa (37) Light smokers: < 1
pack/ day
OR: 2.2 (0.87 – 7.83) Case Control

Ectopic Pregnancy (38) < 10 cig/day OR: 1.4 (0.8 – 2.5) Case Control

Other Conditions

Ankle Fractures in Women
(39)
1–10 cig/day OR: 3.0 (1.9 – 4.6) Retrospective

Cataracts/ Development of
Nuclear Lens Opacities (40)
Light smoking (< 10
cig/ day)
OR: 1.68 (1.14 – 2.49) Prospective Cohort
Physical Disability after
Meniscal Tear (41)
Light smoking (< 1
pack/day)
RH: 1.44 (1.07–1.94) Prospective Cohort

All Cause Mortality
Risk of all cause mortality
in men (31)
Occasional Smoking OR: 1.6 ( 1.3–2.1) Prospective Cohort