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Time course of antagonist effects of nor-BNI (0.32 mg) administered locally in the tail against local U50,488 (top) and bremazocine (bottom) in 46°C water in the presence of capsaicin. Asterisks represent a significant difference (p < .01) from cap + U50. The label cap + brem represents the effects of coadministration of 0.1 mg of capsaicin and 3.2 μg of bremazocine in the tail. Other details are as in Fig. 3.
