TABLE 1.
Comparison of potencies of κ opioid agonists after local and systemic administration
| Agonists | ED50a (95% CL) | Relative Potenciesb | |
|---|---|---|---|
| Local (mg): in the tail | Systemic (mg/kg): in the back | ||
| U50,488 | 0.026 (0.014–0.049) | 0.186 (0.100–0.350) | 68.7 |
| Dynorphin A(1–13) | 0.028 (0.010–0.081) | NAc | >1000 |
a
ED50 values were the mean of individual values (n = 3–6).
b
Values were the mean of individual relative potencies, which were obtained by converting mg/kg to total mg unit based on each monkey's body weight.
c
Inactive up to 3.2 mg/kg.