. Author manuscript; available in PMC: 2010 May 6.

Published in final edited form as: J Pharmacol Exp Ther. 1999 Apr;289(1):378–385.

TABLE 2.

Comparison of potencies of opioid antagonists administered locally in the tail against U50,488 and bremazocine

Antagonists (μg)	ID ^a (95% CL)		Relative Potencies^b

	versus U50,488	versus bremazocine
Quadazocine	27.8 (17.4–44.4)	53.6 (13.2–218.1)	2.2
Oxilorphan	0.27 (0.12–0.59)	1.82 (0.88–3.87)	7.0^*

ID₅₀ values were the mean of individual values (n = 3).

Values were the mean of individual relative potencies, which were obtained by dividing the ID₅₀ value versus bremazocine by the ID₅₀ value versus U50,488.

Indicates that the ID₅₀ of oxilorphan antagonism of bremazocine is significantly different from that for U50,488.