Table 3.
Moderator Analyses of 8-Week ABC Irritability Subscale Score Ratings: Mean Decrease in ABC Irritability Subscale Score from Baseline
| Moderator | Placebo | Risperidone | Placebo | Risperidone | Interactiona |
|---|---|---|---|---|---|
| Sex | Male | Female | χ2 = 2.21c | ||
| Meanb (SD) | 5.17 (7.43) | 15.25 (10.34) | 0.83 (8.98) | 18.33 (7.48) | p = 0.14 |
| n |
36 |
36 |
6 |
9 |
Pool var = 78.61 |
| Age | >8.15 Years | <8.15 Years | χ2 = 0.16 | ||
| Mean (SD) | 2.87 (8.10) | 14.61 (10.81) | 6.05 (7.34) | 16.70 (9.24) | p = 0.69 |
| n |
23 |
18 |
19 |
27 |
Pool var = 79.75 |
| Education | University Degree | <University Degree | χ2 = 1.61 | ||
| Mean (SD) | 3.70 (7.00) | 13.00 (7.87) | 4.86 (8.66) | 18.61 (10.87) | p = 0.20 |
| n |
20 |
22 |
22 |
23 |
Pool var = 77.18 |
| Ethnicity | Non-Caucasian | Caucasian | χ2 = 0.01c | ||
| Mean (SD) | 4.67 (10.53) | 15.50 (8.82) | 4.11 (6.10) | 16.03 (10.39) | p = 0.91 |
| n |
15 |
14 |
27 |
31 |
Pool var = 81.56 |
| High | Low | ||||
| Income | χ2 = 0.09 | ||||
| Mean (SD) | 5.20 (5.01) | 15.00 (10.43) | 4.48 (8.87) | 16.32 (8.98) | p = 0.76 |
| n |
20 |
25 |
21 |
19 |
Pool var = 75.47 |
| IQ | χ2 = 1.05 | ||||
| Mean (SD) | 2.47 (5.25) | 15.00 (10.25) | 6.74 (8.04) | 16.61 (10.22) | p = 0.30 |
| n |
17 |
23 |
23 |
18 |
Pool var = 75.30 |
| Weight | χ2 = 0.08 | ||||
| Mean (SD) | 5.42 (8.98) | 15.24 (10.21) | 2.83 (5.92) | 16.08 (9.38) | p = 0.78 |
| n |
24 |
17 |
18 |
24 |
Pool var = 77.75 |
| CGI Illness severity | χ2 = 0.10 | ||||
| Mean (SD) | 4.31 (7.30) | 14.23 (8.34) | 4.31 (8.20) | 16.53 (10.43) | p = 0.76 |
| n |
13 |
13 |
29 |
32 |
Pool var = 81.07 |
| ADI-R Social impairment | χ2 = 0.43 | ||||
| Mean (SD) | 4.94 (10.46) | 16.35 (10.76) | 3.88 (5.62) | 15.57 (9.52) | p = 0.51 |
| n |
17 |
17 |
25 |
28 |
Pool var = 82.02 |
| ADI-R Communication impairment | χ2 = 1.01 | ||||
| Mean (SD) | 2.78 (5.53) | 14.35 (10.18) | 5.46 (9.16) | 17.08 (9.58) | p = 0.31 |
| n |
18 |
20 |
24 |
25 |
Pool var = 79.78 |
| ADI-R Stereotypy | χ2 = 0.14 | ||||
| Mean (SD) | 2.47 (6.03) | 13.29 (11.56) | 6.00 (9.09) | 17.43 (8.47) | p = 0.71 |
| n |
19 |
17 |
22 |
28 |
Pool var = 78.84 |
| CY-BOCS | χ2 = 0.08 | ||||
| Mean (SD) | 4.39 (7.22) | 13.75 (10.46) | 4.06 (9.22) | 17.30 (8.61) | p = 0.78 |
| n |
23 |
20 |
17 |
23 |
Pool var = 78.69 |
| ABC Irritability | χ2 = 15.24 | ||||
| Mean (SD) | 5.65 (8.52) | 21.21 (8.99) | 3.09 (7.14) | 9.76 (6.81) | p = 0.00 |
| n |
20 |
24 |
22 |
21 |
Pool var = 63.07 |
| ABC Stereotypy | χ2 = 0.00 | ||||
| Mean (SD) | 3.32 (8.39) | 15.70 (11.91) | 5.13 (7.45) | 16.05 (7.34) | p = 0.95 |
| n |
19 |
23 |
23 |
22 |
Pool var = 81.21 |
| ABC Hyperactivity | χ2 = 2.44 | ||||
| Mean (SD) | 5.31 (7.97) | 18.80 (9.59) | 2.69 (7.59) | 13.52 (9.57) | p = 0.12 |
| n |
26 |
25 |
16 |
20 |
Pool var = 77.10 |
| CSI Inattention | χ2 = 3.03 | ||||
| Mean (SD) | 3.33 (6.79) | 17.68 (9.08) | 5.61 (9.10) | 13.60 (10.49) | p = 0.08 |
| n |
24 |
25 |
18 |
20 |
Pool var = 78.77 |
| CSI Hyperactivity | χ2 = 0.63 | ||||
| Mean (SD) | 5.31 (7.97) | 18.20 (8.53) | 2.69 (7.59) | 12.96 (10.76) | p = 0.43 |
| n |
25 |
25 |
17 |
20 |
Pool var = 77.02 |
| CSI Conduct | χ2 = 3.42 | ||||
| Mean (SD) | 3.65 (8.89) | 18.44 (8.82) | 5.11 (6.51) | 12.65 (10.30) | p = 0.06 |
| n |
23 |
25 |
19 |
20 |
Pool var = 76.92 |
| CSI Oppositional | χ2 = 0.13 | ||||
| Mean (SD) | 4.33 (7.08) | 15.72 (8.39) | 4.28 (8.97) | 16.05 (11.62) | p = 0.71 |
| n |
24 |
25 |
18 |
20 |
Pool var = 81.63 |
| CSI Enuresis | χ2 = 3.06 | ||||
| Mean (SD) | 4.48 (8.75) | 16.93 (9.42) | 4.00 (6.15) | 13.94 (10.57) | p = 0.08 |
| n |
27 |
29 |
15 |
16 |
Pool var = 80.49 |
| CSI Encopresis | χ2 = 2.89 | ||||
| Mean (SD) | 4.26 (9.82) | 19.05 (8.88) | 4.43 (5.97) | 12.83 (9.92) | p = 0.09 |
| n |
19 |
22 |
23 |
23 |
Pool var = 76.39 |
| CSI Anxiety | χ2 = 0.24 | ||||
| Mean (SD) | 6.43 (7.77) | 17.90 (7.82) | 1.74 (7.31) | 14.08 (11.17) | p = 0.62 |
| n |
23 |
21 |
19 |
24 |
Pool var = 76.90 |
| CSI Anorexia | χ2 = 0.10 | ||||
| Mean (SD) | 1.18 (8.27) | 12.64 (10.96) | 5.67 (7.51) | 17.97 (9.05) | p = 0.75 |
| n |
11 |
14 |
30 |
29 |
Pool var = 77.18 |
| CSI Bulimia | χ2 = 0.52 | ||||
| Mean (SD) | 4.00 (9.52) | 17.53 (9.28) | 4.52 (6.67) | 15.38 (10.39) | p = 0.47 |
| n |
17 |
17 |
25 |
26 |
Pool var = 81.41 |
| CSI Depression | χ2 = 3.72 | ||||
| Mean (SD) | 2.59 (8.67) | 17.00 (9.73) | 4.83 (7.11) | 15.57 (10.23) | p = 0.05 |
| n |
17 |
20 |
23 |
23 |
Pool var = 81.21 |
| CSI Bipolar disorder | χ2 = 0.02 | ||||
| Mean (SD) | 4.65 (6.31) | 16.20 (10.53) | 5.13 (8.69) | 16.31 (8.71) | p = 0.90 |
| n |
26 |
30 |
15 |
13 |
Pool var = 77.23 |
| Leptin | χ2 = 0.24 | ||||
| Mean (SD) | 3.42 (8.23) | 14.45 (8.21) | 5.95 (8.10) | 16.57 (10.79) | p = 0.63 |
| n |
19 |
20 |
19 |
23 |
Pool var = 81.07 |
| Prolactin | χ2 = 3.79 | ||||
| Mean (SD) | 4.85 (5.53) | 12.48 (9.69) | 4.32 (10.25) | 19.10 (8.58) | p = 0.05 |
| n |
20 |
21 |
19 |
21 |
Pool var = 75.62 |
| Ferritin | χ2 = 0.15 | ||||
| Mean (SD) | 2.11 (5.43) | 12.82 (9.01) | 8.17 (8.42) | 15.78 (10.16) | p = 0.69 |
| n |
18 |
11 |
12 |
18 |
Pool var = 69.96 |
| Ceruloplasmin | χ2 = 0.04 | ||||
| Mean (SD) | 5.73 (7.41) | 15.00 (7.07) | 3.92 (7.38) | 15.87 (10.09) | p = 0.83 |
| n |
15 |
12 |
12 |
15 |
Pool var = 66.86 |
| CeruloplasminRID | χ2 = 4.87 | ||||
| Mean (SD) | 3.94 (8.12) | 18.55 (5.79) | 5.75 (6.37) | 10.81 (9.01) | p = 0.03 |
| n |
17 |
11 |
12 |
16 |
Pool var = 58.74 |
| Serum zinc | χ2 = 0.19 | ||||
| Mean (SD) | 4.69 (6.55) | 15.65 (9.38) | 4.93 (8.38) | 12.36 (9.91) | p = 0.66 |
| n |
13 |
17 |
15 |
14 |
Pool var = 76.04 |
| Copper | χ2 = 0.21 | ||||
| Mean (SD) | 2.71 (5.31) | 15.36 (8.21) | 4.64 (7.10) | 13.56 (9.98) | p = 0.65 |
| n |
17 |
11 |
11 |
16 |
Pool var = 61.24 |
| 5′-Nucleotidase | χ2 = 0.00 | ||||
| Mean (SD) | 5.43 (6.31) | 14.10 (9.96) | 1.80 (5.80) | 14.29 (9.89) | p = 0.96 |
| n |
14 |
10 |
10 |
14 |
Pool var = 67.84 |
| Serum iron | χ2 = 3.07 | ||||
| Mean (SD) | 2.25 (6.41) | 15.11 (9.58) | 5.57 (9.57) | 12.09 (10.45) | p = 0.08 |
| n | 12 | 9 | 7 | 11 | Pool var = 80.79 |
a
Three-way interaction between Time, Moderator, and Treatment. χ2 is for the Wald Statistic associated with the coefficient of the interaction term in the GLM.
b
Mean decrease in Irritability.
c
Denotes categorical analysis.
Abbreviations: ABC = Aberrant Behavior Checklist; SD = standard deviation; IQ = Intelligence quotient; CGI = Clinical Global Impressions; ADI-R = Autism Diagnostic Interview–Revised; CY-BOCS = Children's Yale-Brown Obsessive Compulsive Scale; CSI = Child Symptom Inventory; RID = radial immunodiffusion.