Table 2.
Results of Cox regression model applied to individual endophenotypes measured in offspring and parental longevity in the combined LLFS sample (Denmark and the United States)
| Covariate | Fathers | Mothers | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Daughters | Sons | All | Daughters | Sons | All | |||||||
| β | N | β | N | β | N | β | N | β | N | β | N | |
| BG | −0.0025 | 355 | 0.0042 | 295 | 0.0005 | 650 | 0.0043* | 374 | 0.0008 | 304 | 0.0021 | 678 |
| BMI | 0.0048 | 359 | 0.0416# | 292 | 0.0154 | 651 | 0.0141 | 374 | 0.0153 | 303 | 0.0153 | 677 |
| CANCER | 0.231* | 389 | −0.0364 | 310 | 0.1049 | 699 | 0.0763 | 408 | −0.0362 | 319 | 0.0368 | 727 |
| CHOL | −0.0018 | 357 | −0.0009 | 298 | −0.0011 | 655 | 0.0025* | 376 | 0.0008 | 307 | 0.0016 | 683 |
| DBP | −0.0022 | 381 | −0.0022 | 306 | −0.0025 | 687 | 0.0083* | 399 | −0.0034 | 315 | 0.0039 | 714 |
| EDUC | 0.0914 | 389 | −0.0178 | 309 | 0.0693 | 698 | 0.284# | 408 | 0.2058 | 318 | 0.2438# | 726 |
| FEV1 | 0 | 317 | 0.0001 | 272 | 0 | 589 | −0.0003* | 332 | −0.0003# | 279 | −0.0002* | 611 |
| FVC | 0.0001 | 317 | 0.0001 | 272 | 0 | 589 | −0.0003* | 332 | −0.0003# | 279 | −0.0001* | 611 |
| GRIP | −0.0125 | 379 | 0.0098 | 304 | −0.0034 | 683 | −0.0181* | 395 | −0.0034 | 313 | −0.004 | 708 |
| HCT | 0.0008 | 346 | −0.0183 | 287 | −0.0098 | 633 | −0.0104 | 362 | −0.0126 | 294 | −0.0099 | 656 |
| HYPERT | −0.0758 | 387 | 0.2202 | 308 | 0.0602 | 695 | −0.0354 | 405 | 0.0312 | 317 | −0.0289 | 722 |
| INCOME | 0.2134 | 376 | 0.1015 | 303 | 0.2025 | 679 | 0.057 | 394 | 0.2123 | 312 | 0.0934 | 706 |
| INTACT | −0.1823 | 325 | 0.1883 | 278 | 0.0697 | 603 | 0.1913 | 334 | −0.1849 | 288 | −0.0156 | 622 |
| MMSE | −0.002 | 372 | 0.0046 | 293 | −0.0009 | 665 | −0.0037 | 389 | −0.0272 | 300 | −0.0108 | 689 |
| MODACT | −0.0814 | 383 | 0.1106 | 310 | 0.0304 | 693 | −0.0229 | 403 | −0.0838 | 319 | −0.0498 | 722 |
| PP | 0.0032 | 381 | −0.0013 | 306 | 0.0021 | 687 | 0.0032 | 399 | 0.005 | 315 | 0.0034 | 714 |
| PR | −0.0089* | 380 | 0.004 | 306 | −0.0034 | 686 | 0.002 | 398 | 0.0083 | 315 | 0.0042 | 713 |
| SBP | 0.0016 | 381 | −0.0013 | 306 | 0.0008 | 687 | 0.0037* | 399 | 0.002 | 315 | 0.0029* | 714 |
0.01 ≤ p <0.05;
p <0.01; for other estimates p ≥ 0.05
β denotes the estimates of respective regression parameters; N signifies the sample size
Abbreviations: BG - fasting blood glucose, BMI - body mass index, CHOL - total cholesterol, DBP (SBP, PP) - diastolic (systolic, pulse) blood pressure, EDUC - low education, FEV1 - forced expiratory volume in 1 second, FVC - forced vital capacity, GRIP - grip strength, HCT - hematocrit, HYPERT – hypertension, INCOME - low income, INTACT - no intensive physical activity, MMSE - total MMSE score, MODACT - no moderate physical activity, PR - pulse rate