. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Mech Ageing Dev. 2010 Feb 23;131(3):215–222. doi: 10.1016/j.mad.2010.02.001

Table 3.

Estimates of the combined effect of 10 physiological variables (i.e., cumulative indices based on respective dichotomized endophenotypes) measured in offspring on parental longevity in the combined LLFS sample (Denmark and the United States) excluding parents with life spans less than 60 years

Cumulative Index	Fathers									Mothers

	Daughters			Sons			All			Daughters			Sons			All

	N1²	N0²	Diff³	N1²	N0²	Diff³	N1²	N0²	Diff³	N1²	N0²	Diff³	N1²	N0²	Diff³	N1²	N0²	Diff³

*Means*¹
PROPHALF⁴	174	160	0.94	146	137	−0.37	320	297	0.34	194	167	−1.0	147	138	−2.27	341	305	−1.55
PROPTERT⁴	71	92	1.24	58	72	1.48	129	164	1.35	83	93	−3.80^*	58	74	−2.87	141	167	−3.40^#
PROPQUAR⁴	38	54	−0.91	33	42	0.3	71	96	−0.37	40	56	−4.33	31	45	−3.64	71	101	−4.03^*
*Tertiles*¹
PROPHALF⁴	185	131	0.17	178	96	1.7	363	227	0.9	205	137	−1.98	175	99	−4.64^§	380	236	−3.15^§
PROPTERT⁴	100	72	−0.15	91	42	1.16	191	114	0.42	113	76	−3.28	89	46	−3.19	202	122	−3.23^*
PROPQUAR⁴	72	46	0.63	55	22	2.16	127	68	1.14	78	46	−3.14	54	22	−4.79	132	68	−3.66^*
*Quartiles*¹
PROPHALF⁴	159	117	−0.39	147	93	1.92	306	210	0.71	173	126	−3.86^#	144	97	−4.35^#	317	223	−4.08^†
PROPTERT⁴	97	75	−0.93	78	57	3.74^*	175	132	1.1	107	78	−4.71^#	80	56	−3.02	187	134	−3.99^#
PROPQUAR⁴	75	51	−1.72	56	31	2.55	131	82	−0.05	77	54	−4.11	56	31	−3.47	133	85	−3.84^*

0.01 ≤ p < 0.05;

0.001 ≤ p < 0.01;

^§

0.0001 ≤ p < 0.001;

^†

p < 0.0001; for other estimates p ≥ 0.05

10 endophenotypes included in calculation of cumulative indices: fasting blood glucose; body mass index; total cholesterol; diastolic, systolic, and pulse pressure; forced expiratory volume in 1 second; forced vital capacity; pulse rate; hematocrit

Means, Tertiles, Quartiles: method of dichotomization of respective EPs based on the observed deviation of values measured in offspring from the average age trajectories of the EPs in the sample (see section “The creation of dichotomous indices”)

N1, N0: numbers of offspring having values of dichotomized EPs “1” (worse health) and “0” (better health), respectively

Diff: difference between mean life spans of parents (fathers or mothers) whose offspring have values of EPs “1” (worse health) and “0” (better health) as defined by the respective dichotomization

⁴

PROPHALF, PROPTERT, PROPQUAR: indices based on cumulative proportions of dichotomized EPs (see section “The creation of indices based on cumulative proportions”)