Table 6b.
Specific genes contributing to enrichment of the term “immune response” after trimming
| Gene | Rank in GWAS | Marker | Genomic Position | p-value (unadjusted) |
|---|---|---|---|---|
| IL23R | 1 | rs11465804 | chr1:67.4 Mb | 1.01E-35 |
| NOD2 | 2 | rs2076756 | chr16:49.2 Mb | 3.42E-32 |
| NKX2-3 | 7 | rs10883371 | chr10:101.2 Mb | 1.82E-10 |
| IRF1 | 17 | rs2188962 | chr5:131.8 Mb | 4.58E-09 |
| TNFSF15 | 39 | rs6478109 | chr9:116.6 Mb | 2.61E-07 |
| CCR6 | 50 | rs7749278 | chr6:167.4 Mb | 3.29E-07 |
| CCL11 | 77 | rs991804 | chr17:29.6 Mb | 4.01E-06 |
| MICA | 88 | rs2596503 | chr6:31.5 Mb | 3.94E-06 |
| HLA-DQA2 | 99 | rs7768538 | chr6:32.8 Mb | 7.92E-06 |
| HLA-C | 121 | rs2905747 | chr6:31.3 Mb | 1.50E-05 |
| IFI30 | 122 | rs7125 | chr19:18.1 Mb | 3.61E-05 |
| PTPN22 | 150 | rs2476601 | chr1:114.2 Mb | 1.81E-05 |
| CSF3 | 160 | rs8078723 | chr17:35.4 Mb | 5.51E-05 |
Genomic position is according to NCBI Build 36.1 of the human genome.
Rank in GWAS is according to the LD-adjusted p-value of the most significant marker associated with each gene. The presented p-value is the unadjusted significance of the specified marker in the original data set.