Figure 4.

AC8 KO mice show normal reference memory for Morris water maze. A, WT and AC8 KO mice were first trained by the visible platform paradigm and showed comparable improvement in escape latency. B, The same set of mice were further trained by the hidden platform paradigm and showed comparable improvement in escape latency. During training, the hidden platform was positioned in the center of a designated quadrant (arbitrarily quadrant 2 as indicated in the inset diagram). C, During the probe trial, both WT and AC8 KO mice spent significantly more time in the target quadrant (quadrant 2). All values are average ± SEM.