FIGURE 6.
Properties of single channel IMO in TRPA1- and TRPA1-TRPV1-expressing sensory neurons. All recordings were performed in cell-attached configuration in voltage clamp mode. MO was applied for 1–2 min. A, representative single channel IMO (25 μm) traces recorded from WT mouse TG neurons at Vh = +60 mV. c, the closed state. Expanded scales of the trace at points 1 and 2 are illustrated. B, representative single channel IMO (25 μm) traces recorded from WT (top) and KO TRPV1 (bottom) mouse TG neurons. Holding potential and mouse lines are indicated. C, summary graph of IMO open probability at +60 and −60 mV in WT and TRPV1 KO TG neurons. Statistical analyses used unpaired t tests; **, p < 0.01, n = 12 for each bar. Error bars, S.E.