Figure 2.

Synphilin-1 attenuated A53T α-synuclein-induced hyperactivity. Novelty-induced activity was measured in cohorts of six to eight mice per group at 4–7 months of age in an open-field test. Horizontal and vertical activities were automatically recorded. The data are presented as the means (beams broken) ± SEM. There was no difference in the novelty-induced activity between mice of various groups at 4 months of age. At 5 and 7 months of age, A53T mice demonstrated significantly increased novelty-induced horizontal and vertical activities compared with mice of other groups (P < 0.001, by statistic analysis with the group by time interaction; P < 0.05 by two-way ANOVA and post hoc Holm–Sidak test). The double-transgenic mice did not display hyperactivity throughout life.