Figure 6.

Synphilin-1 reduced A53T α-synuclein-induced astroglial activation in the brainstem. Sagittal mouse brain sections from 9-month-old mice were subjected to GFAP immunostaining. (A and B) Graph showing the quantification of GFAP-positive cells in the brainstem retrorubal field and facial motor nucleus at 9 months of age. Values represent mean ± SEM. *P < 0.05, versus non-transgenic mice; ^#P < 0.05, versus A53T α-synuclein mice by ANOVA. (C) Representative images of brainstem immunostaining for GFAP in sagittal sections that were matched for level.