Figure 7.

Tcap KO mice exhibit a decline in motor performance by 4 months of age. The ability to maintain balance on a rotating rod was compared between WT and Tcap KO mice by measuring the time (in seconds) to fall from a Rotor Rod. Performance was assessed longitudinally, and compared with WT controls, Tcap KO mice (open circles) exhibited impaired performance relative to controls at 2 months (n = 32, 62±6 versus 77 ± 7 s), 3 months (n = 32, 65 ± 6 versus 72 ± 12 s) and 4 months (n = 30, 56 ± 6 versus 71 ± 7), respectively. Data indicate mean ± SE.