Table 1.

mRNAs differentially expressed^a in age-matched Tcap KO versus WT gastrocnemius muscle

Ratio	Direction	P-value	Gene identifier	Gene name
3.55	Up	0.032	AK043675	Ryanodine receptor 2, cardiac
1.7	Up	0.049	NM_010927	Nitric oxide synthase 2, inducible, macrophage
1.6	Up	0.047	AK171682	Ankyrin repeat, family A (RFXANK-like), 2
1.55	Up	0.039	NM_029891	NF-kappaB repressing factor
1.25	Down	NS	NM_010834	Myostatin
1.05	Up	NS	NM_008046	Follistatin
1.02	Down	NS	NM_008047	Follistatin-like 1
1.08	Up	NS	NM_031380	Follistatin-like 3
1.26	Down	NS	NM_177059	Follistatin-like 4
1.07	Up	NS	AK047518	Follistatin-like 5
1.04	Up	NS	NM_178673	Follistatin-like 5
1.06	Down	NS	NM_010514	IGF-2
1.27	Up	NS	NM_010866	MyoD1 Myogenic Differentiation 1
1.01	Up	NS	NM_031189	Myogenin
1.04	Up	NS	NM_134092	Mdm2, transformed 3T3 cell double minute p53 binding protein
1.01	Up	NS	NM_178939	P53 and DNA damage regulated 1
1.21	Up	NS	NM_011035	P21 (CDKN1A)-activated kinase 1
1.09	Up	NS	NM_177326	P21 (CDKN1A)-activated kinase 2
1.29	Down	NS	NM_008778	P21 (CDKN1A)-activated kinase 3
1.15	Down	NS	NM_027470	P21 (CDKN1A)-activated kinase 4
1.22	Up	NS	AK028788	P21 (CDKN1A)-activated kinase 6
1.57	Up	NS	NM_172858	P21 (CDKN1A)-activated kinase 7
1.06	Up	NS	NM_175246	Smad nuclear interacting protein 1
1	Up	NS	NM_001038627	SMAD specific E3 ubiquitin protein ligase 1
1.21	Up	NS	NM_025481	SMAD specific E3 ubiquitin protein ligase 2
3.03	Up	0.029	AK016833	Transcribed locus, strongly similar to XP_204338.2 PREDICTED: hypothetical protein LOC71159 isoform 1 [Mus musculus]
3.01	Up	0.035	AK014613	Amyloid beta precursor protein (cytoplasmic tail) binding protein 2
2.95	Up	0.023	AK077587	CDNA clone IMAGE:3491339
2.87	Up	0.046	NM_177742	Tripartite motif family-like 1
2.78	Up	0.030	AK053064	gb|Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930038O08 product:unclassifiable, full insert sequence [AK053064]
2.72	Up	0.016	NM_177093	Leucine rich repeat containing 58
2.65	Up	0.048	AK054366	Zinc finger, MIZ-type containing 1
2.56	Up	0.042	NM_177568	Phospholipase C, beta 2
2.48	Up	0.027	NM_175696	RIKEN cDNA C530028O21 gene
2.43	Up	0.012	NM_181858	CD59b antigen
2.42	Up	0.040	NM_146780	Olfactory receptor 715
2.42	Up	0.016	BB161836	Transcribed locus
2.42	Down	0.024	NM_001025607	Predicted gene, EG382275
2.41	Up	0.027	AK044518	RIKEN cDNA A930016P21 gene
2.37	Up	0.029	NM_021885	Tubby candidate gene
2.22	Up	0.017	NM_011164	Prolactin
2.19	Up	0.042	NM_015728	Solute carrier family 33 (acetyl-CoA transporter), member 1
2.16	Up	0.041	AF175408	MAD homolog 9 (Drosophila)
2.08	Up	0.026	NM_019508	Interleukin 17B
2.07	Up	0.042	NM_147061	Olfactory receptor 691
2.04	Up	0.006	AK054195	gb|Mus musculus 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230027A21 product:purinergic receptor P2X-like 1, orphan receptor, full insert sequence [AK054195]
2.02	Up	0.023	AK029221	Transcribed locus
2.01	Down	0.026	NM_019743	RING1 and YY1 binding protein
2	Up	0.030	NM_013912	Apelin
1.98	Down	0.049	NM_001001884	Riken cDNA C230021P08 gene
1.98	Up	0.010	NM_009520	Wingless related MMTV integration site 2b
1.98	Up	0.042	NM_053271	Regulating synaptic membrane exocytosis 2
1.96	Down	0.050	NM_031388	Ubiquitin specific peptidase 26
1.95	Up	0.043	AK166269	Hedgehog interacting protein-like 1
1.94	Down	0.034	NM_030218	RIKEN cDNA 9130017N09 gene
1.94	Down	0.016	AK049328	gb|Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330024F03 product:unclassifiable, full insert sequence [AK049328]
1.94	Up	0.009	AK084222	gb|Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230010D07 product:unclassifiable, full insert sequence [AK084222]
1.93	Up	0.025	NM_008260	Forkhead box A3
1.93	Up	0.033	BC045114	CDNA sequence BC016201
1.92	Up	0.036	AK048563	Transcribed locus, strongly similar to NP_891550.1 ADAM metallopeptidase with thrombospondin type 1 motif, 9 preproprotein [H]
1.92	Up	0.036	TC1744477	tc|Q9Y649_HUMAN (Q9Y649) GW128 (YWHAB protein), partial (16%) [TC1744477]
1.91	Up	0.016	AK033743	Lipocalin 6
1.88	Up	0.031	AK034064	Dedicator of cytokinesis 10
1.87	Down	0.043	NM_029881	RIKEN cDNA C030003D03 gene
1.87	Up	0.018	NM_019694	Leucine zipper-EF-hand containing transmembrane protein 1
1.87	Up	0.022	NM_001099631	SH2 domain-containing 5
1.8	Up	0.019	AK041796	Transcribed locus, strongly similar to NP_006339.2 component of oligomeric golgi complex 5 isoform 1 [Homo sapiens]
1.77	Up	0.019	AK016421	RIKEN cDNA 4931400O07 gene
1.76	Down	0.005	NM_001112729	CDNA sequence BC019943
1.75	Down	0.022	NM_027893	Poliovirus receptor-related 4
1.75	Up	0.036	TC1650944	tc|Q3TLP8_MOUSE (Q3TLP8) Mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930005L08 product:RAS-related C3 botulinum substrate 1, full insert sequence, partial (9%) [TC1650944]
1.75	Up	0.042	NM_145959	DNA segment, Chr 15, ERATO Doi 621, expressed
1.74	Up	0.008	AK142481	Transcribed locus, weakly similar to XP_001479644.1 PREDICTED: hypothetical protein [Mus musculus]
1.74	Up	0.015	ENSMUST00000092674	ens|HBS1-like protein [Source:Uniprot/SWISSPROT;Acc:Q69ZS7] [ENSMUST00000092674]
1.74	Up	0.004	NM_001039655	RAS protein-specific guanine nucleotide-releasing factor 1
1.73	Up	0.045	NM_029663	Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
1.73	Up	0.042	AK050374	Tocopherol (alpha) transfer protein
1.72	Down	0.022	NM_026390	UBX domain-containing 2
1.72	Up	0.038	NM_001081012	RIKEN cDNA 4930473A06 gene
1.71	Up	0.039	AK028249	Ubiquitin specific peptidase 27, X chromosome
1.68	Down	0.012	AK031662	gb|Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030474N09 product:unclassifiable, full insert sequence [AK031662]
1.65	Up	0.035	NM_147032	Olfactory receptor 705
1.64	Up	0.036	NM_001008231	Dishevelled associated activator of morphogenesis 2
1.64	Up	0.013	AK081940	Transcribed locus
1.64	Up	0.038	NM_011218	Protein tyrosine phosphatase, receptor type, S
1.63	Up	0.046	BC037468	gb|Mus musculus cDNA clone IMAGE:4223409 [BC037468]
1.63	Up	0.043	AK046200	gb|Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230350K09 product:unclassifiable, full insert sequence [AK046200]
1.62	Down	0.037	NM_022007	FXYD domain-containing ion transport regulator 7
1.62	Up	0.010	NM_173427	Kelch domain-containing 7A
1.6	Up	0.042	AK053298	gb|Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130008E24 product:surfactant associated protein B, full insert sequence [AK053298]
1.6	Up	0.022	AK005365	G protein-coupled receptor kinase-interactor 2
1.6	Up	0.044	NM_181400	WD repeat domain 47
1.6	Up	0.034	AK080744	PIH1 domain-containing 2
1.6	Up	0.030	NM_026563	Serologically defined colon cancer antigen 3
1.59	Down	0.049	NM_176835	RIKEN cDNA 2810451A06 gene
1.59	Down	0.048	AK046930	Transcribed locus
1.57	Up	0.010	NM_010154	V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
1.56	Up	0.039	NM_031199	Transforming growth factor alpha
1.55	Up	0.041	AK079838	Glutaminase
1.55	Up	0.047	AK133637	Protocadherin 17
1.54	Up	0.031	NM_009215	Somatostatin
1.54	Up	0.049	NM_009288	Serine/threonine kinase 10
1.54	Up	0.014	AK139092	CDNA clone IMAGE:574497
1.53	Up	0.047	NM_001081182	Atpase, class I, type 8B, member 2
1.51	Down	0.041	AK054138	SUMO/sentrin specific peptidase 6
1.5	Up	0.048	NM_207683	Phosphatidylinositol 3-kinase, C2 domain-containing, gamma polypeptide

Changes (ratio) are relative to control where control = 1.00; Up, Up-regulation; Down, Down-regulation. Student's t-test values are shown, n = 6 microarrays (three per group).

^aMuscle regulatory factors and cell cycle regulators of special interest that were assayed but not significantly different (NS) between KO and WT tissue are included.