Table I.

Decrease of splenic B cell numbers in anti-B cell Ab-treated mice^a

Clone	Specificity	B6	B6/lpr	MRL/lpr
1D3, rIgG2a	Anti-CD19	10–20%	NC	NC1
7G6, rIgG2b	Anti-CD21	ND	ND	ND/NC1
2D6, rIgG1	Anti-CD22	NC	ND	ND/NC1,2
B3B4, rIgG2a	Anti-CD23	NC	ND	ND/NC2
30F1, rIgG2a	Anti-CD24	10–20%	40%	40%/NC2
RA3-6B2, rIgG2a	Anti-CD45R/B220	10–20%	10–20%	ND/NC2
HM79-16, hamster IgG	Anti-CD79β	60%	40%	25%

^aShown are average percentage decreases of splenic B cell numbers 1 wk after injection of 1 mg Ab (n = 2–3/treatment). MRL/lpr mice were further screened with some of these clones and were given:

¹three weekly injections of either PBS or 0.5 mg Ab, or

²three weekly injections of either PBS or 0.3 mg daunomycin-conjugated antibody. In anti-B220 treated mice, CD19⁺ cells were enumerated as B cells. In other Ab-treated mice, B220⁺sIgM⁺ cells were enumerated as B cells. NC indicates no change.