Skip to main content
. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Neurobiol Aging. 2008 Jun 20;31(3):425–433. doi: 10.1016/j.neurobiolaging.2008.05.009

Figure 1. Effects of 3-month chronic treatment with EUK-189 or EUK-207 on context fear conditioning.

Figure 1

17 month-old mice were treated for 3 months with a low (0.15 mM) or a high (1.5 mM) concentration of EUK-189 or EUK-207 and then trained in a contextual fear conditioning paradigm and tested 24 h after training. Results were calculated as percent time the mouse expressed freezing behavior during the 8-min observation period for context minus the percent time the mouse expressed freezing behavior prior to training. Shown are means ± SEM of 9-17 mice. One-way ANOVA indicated that the effect of age was significant (*p <0.05 vs. 16 month-old mice), as was the effect of EUK-189 and EUK-207 (**p <0.05 vs. vehicle control).