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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Neurobiol Aging. 2008 Jun 20;31(3):425–433. doi: 10.1016/j.neurobiolaging.2008.05.009

Figure 3. Effects of chronic treatment with EUK-189 or EUK-207 on lipid peroxidation in brain homogenates.

Figure 3

At the end of the 6 month treatment, mice were decapitated and their brains (minus cerebellum and pons) were removed and homogenized. Lipid peroxidation was then quantified by the thiobarbituric acid-reactive substances (TBARS) assay. Lipid peroxidation was also determined in brain homogenates from 16 month-old control mice. Levels of lipid peroxidation were expressed as nmol malondialdehyde equivalent per mg of protein. Shown are means ± SEM of 8-10 mice. One-way ANOVA indicated that the effect of age was highly significant (*p <0.001 vs. 16 month-old mice), as was the effect of EUK-189 and EUK-207 (**p <0.001 vs. vehicle control).