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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Neurobiol Aging. 2008 Jun 20;31(3):425–433. doi: 10.1016/j.neurobiolaging.2008.05.009

Figure 4. Effects of chronic treatment with EUK-189 or EUK-207 on reactive oxygen species (ROS) levels in brain homogenates.

Figure 4

At the end of the 6-month treatment, brain ROS content was quantified by incubating brain homogenates with 2′-7-dichlorofluorescein diacetate (DCFH-DA). ROS content was also determined in brain homogenates from 16 month-old control mice. Results were expressed as percentage of 16 month value. Shown are means ± SEM of 8-10 mice. One-way ANOVA indicated that the effect of age was highly significant (*p <0.001 vs. 16 month-old mice), as was the effect of EUK-189 and EUK-207 (**p <0.001 vs. vehicle control).