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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Neurobiol Aging. 2008 Jun 20;31(3):425–433. doi: 10.1016/j.neurobiolaging.2008.05.009

Figure 5. Effects of chronic treatment with EUK-189 or EUK-207 on oxidized nucleic acids in brain homogenates.

Figure 5

At the end of the 6-month treatment, oxidized guanine was quantified by extracting DNA from brain homogenates and then blotting onto a membrane, which was then probed with an anti-oxo8dG/oxoG antibody. Oxidized nucleic acid content was also determined in brain homogenates from 16 month-old control mice. (A) Representative 8oxoG dot blot. (B) Results were expressed as percentage of 16 month value. Shown are means ± SEM of 8-10 mice. One-way ANOVA indicated that the effect of age was significant (*p <0.05 vs. 16 month-old mice), as was the effect of EUK-189 and EUK-207 (**p <0.05 vs. vehicle control, ***p <0.01 vs. vehicle control).