Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Mar 29;10:36. doi: 10.1186/1471-213X-10-36

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2010 Ge and Stanley; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Embryogenesis in Notch1^12f/lbdembryos. (A-D) Vascularization of yolk sac in Notch1^+/12f, Notch1^12f/12f, Notch1^12f/lbdand Notchl^lbd/lbdembryos at E9.5. Large vitelline blood vessels were present in Notch1^+/12fand Notch1^12f/12fyolk sacs, but absent in the Notch1^12f/lbdand Notch1^lbd/lbdmutants. (E-H) Morphology of embryos at E9.5. Notch1^12f/12fare similiar to Notch1^+/12f, Notch1^12f/lbdare markedly underdeveloped, and Notch1^lbd/lbdare severely underdeveloped. (I-L) Notch1^12f/lbdembryos from E10.5-E12.5. White arrows show hemorrhaging in E10.5 and E11.5 embryos; most E12.5 embryos were resorbing. The number of embryos examined at each stage is given in Table 1.