Table 2.
Notch112f/tm1Con pups may survive to birth
| Stage | 12f/12f × +/tm1Con | 12f/12f × +/lbd | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Litters | Pups | +/12f | 12f/tm1Con | Litters | Pups | +/12f | 12f/lbd | ||||
| E9.5 | 3 | 23 | 11 | 12 | 5 | 38 | 18 | 20 | |||
| E10.5 | 3 | 23 | 13 | 10 | 8 | 70 | 37 | 33 | |||
| E11.5 | 4 | 24 | 16 | 8 | 7 | 48 | 28 | 20 | |||
| E12.5 | 5 | 25 | 21 | 4 | 8 | 33 | 28 | 5 | |||
| E13.5 | 5 | 27 | 21 | 6 | 5 | 23 | 23 | 0 | |||
| E15.5 | 3 | 13 | 9 | 4 | - | - | - | - | |||
| E17.5 | 5 | 19 | 17 | 2 | - | - | - | - | |||
| P1 | 6 | 25 | 23 | 2 | - | - | - | - | |||
| Wean | 13 | 50 | 50 | 0 | 8 | 30 | 30 | 0 | |||
Embryos (E9.5 -- E17.5), post-natal pups (P1) and mice after weaning were genotyped from crosses of Notch112f/12f female × Notch1+/tm1Con male or crosses of Notch112f/12f female × Notch1+/lbd male. The data from Notch1+/12f × Notch112f/lbd crosses were previously published [12] but are included for ease of comparison.