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PLA2 inhibitors protected hippocampal neurones against PrP82-146 induced synapse degeneration. The synaptophysin content of cultured hippocampal neurones pre-treated with a vehicle control (■), 1 μM AACOCF3 (○) or 1 μM MAFP (●) and incubated with varying concentrations of PrP82-146 for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 9.
