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PrP82-146 increased activation of cPLA2 in synapses. Correlation between the amounts of activated cPLA2 in synaptosomes isolated from primary cortical neurones 1 hour after the addition of varying concentrations of PrP82-146 and the amount of synaptophysin in cell extracts from primary cortical neurones incubated for 24 hours with the same concentrations of PrP82-146.
