Table 3.

A prostanoid E receptor antagonist protected against synapse degeneration

	Synaptophysin (units)
Treatment	Vehicle control	Prostanoid E receptor antagonist AH13205	Prostanoid D receptor antagonist BWA868C
Vehicle control	100 ± 6	99 ± 7	99 ± 3
200 nM PrP82-146	22 ± 5	87 ± 8	30 ± 7
100 nM Aβ1-42	32 ± 6	93 ± 5	34 ± 6
1 μM PLAP	27 ± 7	91 ± 7	38 ± 6
10 nM PAF	31 ± 4	85 ± 9	32 ± 5
10 nM Prostaglandin E2	30 ± 5	97 ± 3	33 ± 6

Primary cortical neurones were pre-treated with a vehicle control, a prostanoid E receptor antagonist (100 nM AH13205) or a prostanoid D receptor antagonist (100 nM BWA868C) for 1 hour prior to incubation with PrP82-146, Aβ_1-42, PLAP, PAF or prostaglandin E₂ as shown for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 9.