Table 1.

Sources of innovation and improvement in protein diagnostics.

• Biomarker discovery, verification, and validation
• Application of new analytical technologies	Mass spectrometry
	Multiplex immunoassay
	New detection methodologies
	Methods for protein fractionation
• Platform engineering	Automation
	Analysis time
	Miniaturization
• Reagent development	New capture reagents
	New labeling reagents
	Stabilization of reagents
• Interpretation	New clinical data
	New diagnostic algorithns
• Preanalytical processes	Patient preparation
	Specimen collection and processing
• Standardization	Development of reference materials
	Development of reference methods
• QC and proficiency testing