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. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44

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Copyright ©2010 McHugh et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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NAGly-induced BV-2 microglial migration is G_i/o-receptor mediated and can be antagonized. (A) BV-2 microglial migration in response to basal conditions; vh (0.1% DMSO); 1 μM fMLP; 1 μM fMLP + 100 nM SR144528; 1 μM NAGly; 1 μM NAGly + 1 μM SR141716A; 1 μM NAGly + 100 nM SR141716A; 1 μM NAGly + 100 nM SR144528;. ** = P < 0.01 compared to 1 μM NAGly; tt = P < 0.01 compared to 1 μM fMLP; Student's unpaired t-test; n = 3. (B) BV-2 microglial migration in response to 0.1 nM - 10 μM NAGly ± 1 μM O-1918, ± 1 μM ARA-S, or ± 24 h pre-treatment with 1 μg/ml PTX; n = 3.