Table 1.
Comparison of the zebra finch, chicken, human, and mouse degradomes
| Gene | Zebra finch | Chicken | Human | Mouse |
|---|---|---|---|---|
| Apoptosis | ||||
| Caspase-1, -4, -5, -12 | Not found | Only caspase-1 | All | All |
| Caspase-17 | Not found | Present | Absent | Absent |
| Caspase-18 | Present | Present | Absent | Absent |
| Host defense | ||||
| Granzyme K | Absent | Absent | Present | Present |
| Neutrophil elastase | Absent | Absent | Present | Present |
| Complement factor D | Absent | Absent | Present | Present |
| Azurocidin | Absent | Absent | Present | Absent |
| Proteinase 3 | Absent | Absent | Present | Present |
| Granzymes B and H, cathepsin G, chymase | Granzyme Z and Z-like | Granzyme Z | All | All |
| PRSS33 | Absent | Absent | Present | Present |
| Tryptases | Absent | Absent | Present | Present |
| Haptoglobins | Absent | Absent | Two | One |
| Cathepsin F | Absent | Absent | Present | Present |
| Cathepsin W | Absent | Absent | Present | Present |
| PRSS16 | Absent | Absent | Present | Present |
| Paracaspase | Triplicated | Triplicated | Present | Present |
| Legumain-2 | Absent | Absent | Present | Present |
| Tissue development | ||||
| Enamelysin | Absent | Absent | Present | Present |
| Kallikrein-4 | Absent | Absent | Present | Present |
| MMP-7, -8, -19, -21, -23B, -25 | Absent | Absent | Present | Present |
| MMP-26 | Absent | Absent | Present | Absent |
| ADAMTS-4 | Absent | Absent | Present | Present |
| Reproduction | ||||
| Alpha-aspartyl dipeptidase | Present | Present | Absent | Absent |
| Nothepsin | Present | Present | Absent | Absent |
| ADAMTS-16 | Absent | Absent | Present | Present |
| Testins | Absent | Absent | Present | Present |
| ADAM3B, -4,-4B,-5,-6 | Absent | Absent | Pseudogenes | Present |
| ADAM7 | Absent | Absent | Present | Present |
| ADAM30 | Absent | Absent | Present | Present |
| Acrosin | Expanded | Present | Present | Present |
| Prolactin-induced protein | Absent | Absent | Present | Present |
| Ovastacin | Absent | Absent | Present | Present |
| ISP1 | Absent | Absent | Absent | Present |
| ISP2 | Absent | Absent | Pseudogene | Present |
| Choryolytic enzymes | Present | Present | Absent | Absent |
| Neural development | ||||
| Caspase-3 | Duplicated | Present | Present | Present |
| Neurotrypsin | Duplicated | Duplicated | Present | Present |
| Bace | Duplicated | Present | Present | Present |
| Presenilin homolog-2 | Absent | Absent | Present | Present |
| Transmembrane serine protease 5 | Absent | Present | Present | Present |
| Brain serine protease-2 | Absent | Absent | Present | Present |
| Other | ||||
| Pepsinogen A | Duplicated | Duplicated | Triplicated | Present |
| Pepsinogen C | Not found | Present | Present | Present |
| ADAMTS-13 | Duplicated | Present | Present | Present |
| Tubulointerstitial nephritis antigen-like 1 | Absent | Absent | Present | Present |
| Desert hedgehog protein | Absent | Absent | Present | Present |
| Sentrin-3 | Absent | Absent | Present | Present |
| Autophagin-4 | Absent | Absent | Present | Present |
| NAALADASE like 1 | Absent | Absent | Present | Present |
| Transferrin receptor 2 | Absent | Absent | Present | Present |
| Dipeptidyl-peptidase 3 | Absent | Absent | Present | Present |
| Vitellogenic-like carboxypeptidase | Absent | Absent | Present | Present |
| ClpP caseinolytic peptidase | Absent | Absent | Present | Present |
| Abhydrolase domain containing 4 | Absent | Absent | Present | Present |
| Polyserases | One | One | Three | Three |
| Kallikreins | Absent | Absent | Present | Present |
| Ubiquitin-specific protease-11 | Absent | Absent | Present | Present |