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. 2010 May 6;6(5):e1000767. doi: 10.1371/journal.pcbi.1000767

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Mendez et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Upper plot: Simulation results for average misfolding stability versus unfolding stability for various mutation biases, three population sizes and neutrality exponent (non-neutral regime) and (neutral regime). Bottom plot: Estimated misfolding versus unfolding stability for families of homologous proteins in prokaryotic genomes (data from Ref. [12]). We distinguish genomes according to content at third codon position. The solid line represents a linear fit of misfolding stability for genomes with moderate or no mutation bias ().

Inline graphic — Upper plot: Simulation results for average misfolding stability versus unfolding stability for various mutation biases, three population sizes and neutrality exponent (non-neutral regime) and (neutral regime). Bottom plot: Estimated misfolding versus unfolding stability for families of homologous proteins in prokaryotic genomes (data from Ref. [12]). We distinguish genomes according to content at third codon position. The solid line represents a linear fit of misfolding stability for genomes with moderate or no mutation bias ().