. 2010 May 6;6(5):e1000896. doi: 10.1371/journal.ppat.1000896

Table 2. Mutation types and frequencies.

			Non-redundant mutations^b
Virus	No. of clones	Total nt sequenced^a	NS	Syn	NCR	Indel	Total	NS:Syn	Ts:Tv^c	Substitution frequency^d
SARS-WT	10	296,468	6	0	0	1	7	n.a.	1.0	2.02E-05
S-ExoN1	10	296,471	49	44	6	1	100	1.1	5.2	3.34E-04

ant, nucleotides. Values are sums for all P3 clones of each virus.

bValues are derived from the aggregate of all P3 clones for each virus and include shared and unique non-engineered mutations. Each shared mutation was counted only once. Substitutions were categorized as NS, nonsynonymous; Syn, synonymous; or NCR, non-coding region. Indel, insertion or deletion. A T25783A mutation in S-ExoN1 clone 34, which is Syn in ORF 3a but NS in ORF 3b, was categorized as NS here and in Figure 5.

cTs, transition; Tv, transversion.

dSubstitution frequency was calculated by dividing the sum of NS, Syn, and NCR mutations by the total number of nucleotides sequenced.