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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Ann Biomed Eng. 2009 Dec 24;38(4):1607–1617. doi: 10.1007/s10439-009-9881-0

FIGURE 3.

FIGURE 3

Carbonate/phosphate ratio (a, indication of carbonate substituting for phosphate in the crystal lattice), mineral/matrix ratio (b, indicative of the relative amount of mineral), collagen crosslinking ratio (c, indicative of the ratio of non-reducible to reducible crosslinking), and crystallinity (d, indicative of the size, shape, and perfection of mineral crystals) as measured by Raman spectroscopy. There was a significant increase in the carbonate/phosphate ratio with exercise in B6;129 (p = 0.034) and C3H (p < 0.001) wild type mice. In B6;129 bgn-deficient mice, there was a significant increase in carbonate/phosphate ratio with exercise (p = 0.012) which was inbred strain-specific. In C3H WT mice, there was a significant increase in mineral/matrix ratio vs. control mice (p = 0.030) which was inbred strain-specific. Inbred strain-specific increases in the collagen cross-linking ratio were present in both WT (p = 0.003) and KO (p = 0.024) C3H mice compared with control mice. Finally, there was an inbred strain specific decrease in crystallinity with exercise in B6;129 KO mice (p = 0.020). Data are presented as mean ± SEM.