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. Author manuscript; available in PMC: 2011 May 13.
Published in final edited form as: J Med Chem. 2010 May 13;53(9):3632–3644. doi: 10.1021/jm1000612

Scheme 1a.

Scheme 1a

a Reagents and conditions: (a) EDC, HOBt, 2,6-lutidine, DMF, 0 °C to rt; (b) HF-pyridine, rt; (c) DAST, CH2Cl2, −78 °C; (d) BrCCl3, DBU, CH3CN, 0 °C to rt; (e) for R=H, LiOH, THF/H2O, Δ; for R=Br, LiBr, DBU, THF/H2O, Δ.