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. Author manuscript; available in PMC: 2011 May 13.
Published in final edited form as: J Med Chem. 2010 May 13;53(9):3632–3644. doi: 10.1021/jm1000612

Scheme 6a.

Scheme 6a

a Reagents and conditions: (a) 2, EDC, HOBt, 2,6-lutidine, DMF, 0 °C to rt; (b) Br(CH2)3NPhth, DBU, DMF, 60 °C; (c) HF-pyridine, rt; (d) DAST, CH2Cl2, −78 °C; (e) BrCCl3, DBU, CH2Cl2, 0 °C to rt; (f) LiCl, DMF, Δ; (g) 1,3-bis(aminomethyl)benzene or 12 or 14, (2 mM in DMF), EDC, HOBT, 2,6-lutidine, rt, 2 d; (h) H2NNH2.H2O, EtOH, Δ.