. Author manuscript; available in PMC: 2011 May 13.

Published in final edited form as: J Med Chem. 2010 May 13;53(9):3632–3644. doi: 10.1021/jm1000612

Table 2.

Impact of HXDV and Various Macrocyclic Pyridyl Polyoxazoles on the Thermal Stabilities of the Duplex and Quadruplex Forms of DNA and RNA

	Change in Thermal Stability, ΔT_tran^a (°C)
Compound	ST Duplex DNA	poly(rA)•poly(rU) Duplex RNA	hTel Quadruplex DNA	AurA Quadruplex RNA
HXDV	0	0	11.5	19.5
6a	0	0	7.5	ND
11b	0	0	0	ND
18	0	0.5	21.0	ND
19	0	0.5	20.5	37.0

ΔT_tran reflects the change in transition temperature (T_tran) of the target nucleic acid induced by the presence of the compound. Values of T_tran were determined from the maxima or minima of first-derivative UV melting profiles exemplified by those shown in Figure 2. The uncertainty in the ΔT_tran values is ±0.5 °C. ND denotes not determined.