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Schematic of the sinus node action potential and key players thought to contribute to spontaneous diastolic depolarization: If = hyperpolarization-activated non-selective cation current or “funny” current; IK = deactivation of delayed rectifier current; Ist = sustained inward current; ICa-L = L-type calcium channel current and ICa-T = T-type calcium channel current; “Calcium Clock” (see text for further details).
