Table 1.
Mutation | Patients (pt) |
Bradycardia at Rest |
Symptoms | Chronotropic Incompetence |
Need for Permanent Pacemaker |
Loss of Channel Function Due to |
|
---|---|---|---|---|---|---|---|
Trafficking Defect |
Change in Biophysical Properties |
||||||
573× 20 | Single pt | Yes | Syncope | Yes | Yes | No | Yes |
D553N21 | Single pt | Yes | Syncope | No | Yes | Yes | No |
S672R19 | One family | Yes | No | No | No | No | Yes |
G480R22 | One family | Yes | No | No | No | Yes | Yes |
A585V46 | Three families | Yes | Presyncope | No | No | Yes | Yes |