Table 4.

Prediction of prostate cancer: univariate and multivariable analyses of rs198977, hK2 level, and the interaction between rs198977 and hK2 level.

	CAPS1			CAPS2			CAPS1 + CAPS2
	707 controls, 189 cases			893 controls, 143 cases			1600 controls, 332 cases
	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value
Univariate
Any T allele*	1.48	1.07, 2.04	0.018	1.15	0.81, 1.64	0.4	1.29	1.02, 1.64	0.034
Controlling for hK2
Any T allele*	3.10	2.11, 4.55	<0.0005	2.07	1.38, 3.09	<0.0005	2.55	1.94, 3.37	<0.0005
Log hK2	3.24	2.57, 4.08	<0.0005	3.63	2.82, 4.67	<0.0005	3.43	2.90, 4.07	<0.0005
Interaction analysis
Any T allele*	0.34	0.10, 1.19	0.091	0.20	0.05, 0.82	0.025	0.27	0.11, 0.68	0.005
Log hK2	4.98	3.50, 7.09	<0.0005	6.14	4.03, 9.36	<0.0005	5.51	4.21, 7.22	<0.0005
Interaction	0.43	0.27, 0.69	<0.0005	0.41	0.24, 0.69	0.0008	0.42	0.30, 0.60	<0.0005

^*Heterozygous genotypes were encoded as intermediate between C/C and T/T genotypes.